fbpx

OROMUCOSAL DELIVERY SYSTEM

WHAT ARE OROMUCOSAL DELIVERY SYSTEM?

Oromucosal delivery systems involve administering active substances through the mucous membranes of the oral cavity, such as the mouth or gums.

Benefits of oromucosal delivery system:

Rapid Absorption: The mucous membranes in the oral cavity allow for quick absorption, leading to faster onset of action compared to conventional oral route.

Enchanced Bioavailability: Dissolution and absorption into systemic circulation through oral cavity and eliminating first-pass metabolism, results in higher bioavailability and more efficient outcomes.

Avoidance of First-Pass Metabolism: Substances absorbed through oromucosal routes bypass the liver initially, reducing the risk of metabolism and enhancing bioavailability.

Compliance: Oromucosal formulations are often user-friendly, making them convenient for administration without the need for water. They are also ideal for companion animals, eliminating the need to mix with food or water or to be swallowed.

Dose Precision: Each individually packed strip refers one dose allowing for better control over dosing, promoting more accurate and consistent administration.

High Quality Standards: Utilizing cutting edge-technology and high quality ingredient requirement in formulations

Reduced GI Side Effects: Since primarly product dissolves in oral cavity absorption, it can minimize gastrointestinal irritation and side effects associated with gastrointestinal system.

Treatment of Acute Conditions: The rapid onset of action makes oromucosal delivery suitable for managing acute conditions where quick relief is essential.

Due to having a rich blood supply and being highly vascularized in the oral mucosa, active ingredients are primarly absorpbed through the oral buccal mucosa and directly enter the systemic circulation, bypassing the gastrointestinal tract and first-pass metabolism in the liver. This results in a rapid onset of action with a more comfortable and convenient delivery route. Although not all active ingredients can enter the bloodstream through the oral mucosa due their mode of actions and characteristics, oromucosal delivery systems enable efficient and convenient administration without the need for water or swallowing.

Enhanced Bioavailability: Dissolution and absorption into systemic circulation through oral cavity and eliminating first-pass metabolism, results in higher bioavailability and more efficient therapeutic outcomes.

Avoidance of First-Pass Metabolism: Substances absorbed through oromucosal routes bypass the liver initially, reducing the risk of metabolism and enhancing bioavailability.

Compliance: Oromucosal formulations are often user-friendly, making it convenient for administration without the need for mixing with food or water.

Dose Precision: The direct delivery allows for better control over dosing, promoting more accurate and consistent administration.

Reduced GI Side Effects: Since oromucosal delivery avoids the digestive tract, it can minimize gastrointestinal irritation and side effects associated with oral medications.

Treatment of Acute Conditions: The rapid onset of action makes oromucosal delivery suitable for managing acute conditions where quick relief is essential.

Due to having a rich blood supply and being highly vascularized in the oral mucosa, active ingredients are immediately absorbed through the oral buccal mucosa and directly enter the systemic circulation, bypassing the gastrointestinal tract and first-pass metabolism in the liver. This results in a rapid onset of action with a more comfortable and convenient delivery route.

The Oral Mucosa: The oral mucosa is characterized by its high permeability, attributed to the non-keratinized nature of the buccal epithelium. Additionally, the limited development of tight junctions and a substantial surface area contribute to the effortless and rapid absorption of active ingredients into the bloodstream.

Easy and fast transportation of active ingredients from the oral mucosa into the bloodstream.

OROMUCOSAL DELIVERY SYSTEMS OPTIMIZE ABSORPTION, ENHANCE BIOAVAILABILITY, AND CONSEQUENTLY, FACILITATE RAPID AND EFFECTIVE ACTIONS

ORALLY DISSOLVING FILM TECHNOLOGY

An Advanced Pharmaceutical Dosage Form: Fast Dissolving Oral Strips (FDSs)

Orally Dissolving Film (ODF) is an innovative pharmaceutical delivery system comprising thin, flexible strips that rapidly disintegrate and dissolve in the oral cavity without the need for water or chewing. This delivery form enhances the solubility, absorption, and bioavailability of active pharmaceutical ingredients while enabling efficient, convenient, and high-compliant administration, particularly for populations with swallowing difficulties or the need for rapid onset of action.

Zoeuticals’ fast-dissolving strips consist of single, flavorful sheets containing potent, intelligently formulated active ingredients. When placed in the mouth, these strips adhere and dissolve rapidly without the need for water, chewing, or swallowing, ensuring swift absorption. The noticeable enhancement in absorption rate and bioavailability, improved user compliance, and the use of high-quality, pure active and inactive ingredients—while requiring fewer inactive excipients—coupled with a significant taste-masking effect, underscore the efficacy and appeal of our oral strips.

 

Clinical and non-clinical studies consistently establish the superior pharmacokinetics of fast dissolving strips (films) when compared to conventional digestion-based delivery systems. Numerous investigations demonstrate that orally administered fast dissolving strips (films) consistently exhibit higher absorption rates and bioavailability values than traditional dosage forms.

By integrating innovation into our product development, we aim to revolutionize how supplements are delivered, making them more accessible and effective for all. Our commitment to quality and efficacy in both human and pet health supplements exemplifies our dedication to advancing healthcare through value-added solutions that truly benefit our customers and their beloved pets.

References
1.⁠ ⁠Farghaly et al., Oral Dissolving Film of Rivastigmine: Optimization Using Factorial Design, Journal of Pharmaceutical Innovation, 2023, https://doi.org/10.1007/s12247-023-09743-4
2.⁠ ⁠Lee et al.,2021, ‘Anti-aging effect of an oral disintegrating collagen film: a prospective, single-arm study’, International Journal of Dermatology, doi: 10.1111/ijd.15675
3.⁠ ⁠Ying Zhu et al., ‘Effect of taste masking technology on fast dissolving oral film: dissolution rate and bioavailability 2018 Nanotechnology 29 304001
4.⁠ ⁠Sattar et al., ‘Oral transmucosal drug delivery – Current status and future prospects’ International Journal of Pharmaceutics, 2014, Volume 471, Issues 1–2, 25 August 2014, Pages 498-506
5.⁠ ⁠Sayed et al., ‘Fast-Dissolving Sublingual Films of Terbutaline Sulfate: Formulation and In Vitro/In Vivo Evaluation, Moleculer Pharmaceuticals, dx.doi.org/10.1021/mp4000713 | Mol.
6.⁠ ⁠Zhang et al.,2002 ‘ Oral Mucosal Drug Delivery, Clinical Pharmacokinetics and Therapeutic Applications, Clin Pharmacokinet; 41 (9): 661-680 0312-5963/02/0009-0661/$25.00/0
7.⁠ ⁠Zhu Y. et al., 2018, ‘ Effect of taste masking technology on fast dissolving oral film: dissolution rate and
8.⁠ ⁠Bioavailability’ https://doi.org/10.1088/1361-6528/aac010, Nanotechnology 29
9.⁠ ⁠Farghaly D. et al., 2023 ‘Oral Dissolving Film of Rivastigmine: Optimization Using
Factorial Design’, Journal of Pharmaceutical Innovation, https://doi.org/10.1007/s12247-023-09743-4