Description

ZOEUTICALS NANO VITAMIN E AND SELENIUM

 AN ADVANCED NANO DELIVERY SYSTEM FOR ENHANCED ABSORPTION AND UTILIZATION

 Composition

Active Ingredients per Bottle

 Produced with nanotechnology to enhance absorption and bioavailability of each component for maximum utilization.

Uses:

Recommended to be used for improving hatchability of eggs.
Helps chick survival during stressful conditions and supports immune system for all lifecycles. Aids in preserving and upholding the integrity of structural tissues. Vital for both growth and reproduction and helps treatment of wry neck. Facilitates the development of the nervous system.

Vitamin E and Selenium are powerful antioxidants formulated using nanotechnology to enhance absorption. Vitamin E is crucial for stabilizing unsaturated fatty acids. Its primary role as an antioxidant involves preventing the generation of harmful free radicals and the oxidation of unsaturated fatty acids in the body, particularly during periods of disease or stress. Meanwhile, selenium, an essential mineral, is a key component of the enzyme glutathione peroxidase. This enzyme plays a vital role in safeguarding cells by neutralizing oxidizing agents such as free radicals and oxidized unsaturated fatty acids.

Directions:  Poultry 1 bottle/2000 L drinking water for 3 – 5 days.  Chicks (< 21 days): 1 bottle/1000 L drinking water for 3 – 5 days. Always provide the animals with fresh drinking water.

For use poultry animals only. This product is intended for supplemental feeding only. Safe for all poultry. Do not use if product appears to be tampered with or seal is broken. Keep out of reach of children and animals.

Storage Conditions: Store at temperatures between 59-77°F (15-25°C). Keep in a dry place and protect from direct sunlight.

Best Before: 2 years from date of production.

PRODUCT FEATURES

The rate-limiting factor for absorption in the gastrointestinal media is dissolution, as only dissolved actives can enter the bloodstream. This case is a critical factor for absorption and bioavailability in the body. Therefore, a nanotechnology-based formulation and and manufacturing process is designed for Vitamin E and Selenium to enhance dissolution and absorption, increasing bioavailability as well as protecting from gastrointestinal degradation.

A scientifically formulated and manufactured Nano Vitamin E and Selenium liquid supplement for poultry animals contains nano-sized vitamins encapsulated in nano droplets (<200 nm) for direct absorption into the bloodstream. This nano form increases surface area, enhances mucosal permeability, solubility, and higher intestinal absorption, while also preventing degradation in the gastrointestinal tract, such as variations in pH levels, enzymatic breakdown, and inter-animal differences. As a result, there is an astonishing increase in absorption within the body and significantly enhanced bioavailability with lower effective doses.

Studies showed that Nano Selenium has better antioxidant activity and improved performance including increased feed intake and immunological responses than conventional supplementation in poultry animals.

 Studies have also demonstrated that the nano supplementation increases the surface area and surface activity, which enhances absorption and thereby the utilization of vitamins (Ahn, 2010; Cai et al., 2012). Additionally, nano multivitamin supplementation showed higher bioavailability compared to micro vitamin supplements in broiler chickens, providing increased growth performance, immunity, and improvement in feed conversion ratio).

 The primary utilization of nanotechnology in poultry centers around employing nano-sized mineral and vitamins. These elements have the potential to mitigate antagonistic interactions commonly observed with traditional ones in the gastrointestinal tract, aiming to enhance bioavailability and decrease effective doses. Additionally, the improved bioavailability and more efficient utilization of these essential nutrients can positively impact metabolism, concurrently minimizing their excretion into the environment.

KEY FACTS

VITAMIN E

Vitamin E, specifically alpha-tocopherol, serves as a natural powerful antioxidant, enhancing the growth performance and physiological and immunological well-being of broiler chickens. Its capacity to reduce lipid peroxidation and neutralize free radicals in both skeletal muscle and plasma contributes to these benefits. Vitamin E is associated with fertility and hatchability in layers and breeders.

Clinical signs of vitamin E deficiency include conditions such as exudative diathesis, muscular myopathy, and encephalomalacia in chicks, along with subclinical manifestations like slow growth, reduced fertility, and increased susceptibility to health issues. Additionally, Vitamin E plays a crucial role in enhancing immune functions, both humoral and cell-mediated, as highlighted by Rizvi et al. (2014).

Furthermore, Vitamin E protects sub-cellular and cellular membranes’ phospholipids from lipid oxidation, ensuring the maintenance of tissue and cell functionality and morphological integrity. Studies have shown that Vitamin E improves the antioxidant defense, immune response, and physiological functions of birds.

In commercial broilers, dietary supplementation with Vitamin E has been found to significantly enhance immune response and increase antioxidant concentrations in the liver. Vitamin E also aids in disease resistance and prevention by modulating the immune system through macrophage activation and antibody production, as noted by Weber (2009).

SELENIUM

 Selenium (Se), a crucial trace element, holds significant potential in sustaining various physiological functions, body metabolism, cellular homeostasis, maintaining reproductive and productive capabilities and the overall performance of poultry. The increasing importance of Selenium nanoparticles (Se-NPs) is attributed to their impact on nutrient digestibility, medicinal applications, targeted drug delivery systems, and vaccine production. The relevance of Se-nanoparticles lies in their high bioavailability and digestive efficiency. Se-NPs have been associated with elevated relative weights of immune-related organs such as the bursa and thymus, contributing to enhanced immunity and, consequently, influencing egg production and the reproductive performance of poultry.

Selenium supplementation has been shown to enhance the hatchability and fertility rates in chickens, contributing to improved overall performance.

Furthermore, selenium has been observed to increase the weight of bursa and thymus, thereby boosting immunity. In broiler diets, selenium supplementation has proven effective in enhancing Feed Conversion Ratio (FCR) and reducing drip-loss, ultimately leading to improved economic gains and meat quality. The inclusion of organic selenium in poultry diets is associated with increased hatchability and fertility in breeders, reduced mortality, and better FCR in broilers.

In summary, the application of selenium demonstrates significant advantages in improving productive performance and meat quality, while also playing a crucial role in safeguarding poultry health and physiological functions.

References

1. Nabi et al., ‘ Nutraceutical role of selenium nanoparticles in poultry nutrition: a review’, 2020, World’s Poultry Science Journal, DOI: 10.1080/00439339.2020.1789535
2. Sheikhsamani, et al, ‘The Bioavailability and Effects of Nano-Vitamin D3 and Micro-Vitamin D3 on Performance and Bone Characteristics in Broiler Chickens’, Poultry Science Journal, 2022, 10(2): 203-213
3. Topical Animal Health and Production Book ‘Nano-selenium on reproduction and immunocompetence: an emerging progress and prospect in the productivity of poultry research’, Volume 53, article number 324, (2021)
4. Alagawany et al., ‘Nutritional significance of amino acids, vitamins and minerals as nutraceuticals in poultry production and health – a comprehensive review’, 2020, VETERINARY QUARTERLY 2021, VOL. 41, NO. 1, 1–29 https://doi.org/10.1080/01652176.2020.1857887
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7. Fathi et. al, ‘Nanoencapsulation of food ingredients using lipid based delivery systems  http://dx.doi.org/10.1016/j.tifs.2011.08.003, 2012
8. Alida Melse Boonstra, ‘ Bioavailability of Micronutrients From Nutrient-Dense Whole Foods: Zooming in on Dairy, Vegetables, and Fruits https://frontiersin.org/articles/10.3389/fnut.2020.00101/full, 2020
9. Farugui et al, ‘Perfusion Study On Rat Small Intestine Exposed To Cholera Toxin To ObserveAbsorptionOfWaterAndElectrolytesFromALiposomeBasedORS,http://www.alliedacademies.org/parasitic-diseases-diagnosis-therapy/ ISSN: 2591 7846