Description

ZOEUTICALS NANO VITAMIN AD3E

 AN ADVANCED NANO DELIVERY SYSTEM FOR ENHANCED ABSORPTION AND UTILIZATION

 Composition

Active Ingredients per Bottle

  Produced with nanotechnology to enhance absorption and bioavailability of each component for maximum utilization.

Uses:

Recommended for normal embryonic development of chickens and to prevent Vitamin A, D3, E deficiencies for broilers, layers and chickens.

Supports growth and immune system against microbial pathogens as well as hatchability and bone mineral density.

Alleviates stress-related effects and improves their responsiveness to vaccines.

Aids in disease prevention and improvement of feed conversion ratio, and eggshell and meat quality.

Help maintain the healthy intestinal mucosa.

Help prevent broilers fatigue syndrome.

Facilitate the absorption of calcium and phosphorus.

Improves reproductive system and enhance laying production.

Vitamin A is vital for the health of epithelial tissues, lining organs and tracts such as the skin, respiratory, digestive, and urinary systems. It promotes vision, and its deficiency can cause night blindness in poultry.

Vitamin D3 supports muscle and immune function and plays a significant role in cell differentiation and proliferation.

Vitamin E acts as an antioxidant, bolstering the immune system and helps prevent diseases in poultry.

Combining Vitamins A, D3, and E is crucial for optimal health, growth, and productivity in poultry.

Directions: Mix one bottle (8 oz.) with 1000 L drinking water for 5-7 days, as required. Always provide the animals with fresh drinking water.

For use poultry animals only. This product is intended for supplemental feeding only. Safe for all poultry. Do not use if product appears to be tampered with or seal is broken. Keep out of reach of children and animals.

Storage Conditions: Store at temperatures between 59-77°F (15-25°C). Keep in a dry place and protect from direct sunlight.

Best Before: 2 years from date of production.

PRODUCT FEATURES

ALL ESSENTIAL NUTRIENTS IN NANO VESICLES FORM FOR DIRECT ABSORPTION  

The rate-limiting factor for the absorption of Vitamin A, D3, and E in the gastrointestinal media is their water solubility due to their oil-soluble properties. This physicochemical property restricts their absorption and bioavailability in the body. Therefore, a nanotechnology-based formulation and manufacturing process are designed to enhance the bioavailability and absorption of these vitamins by increasing their dissolution in gastrointestinal media and water.

A scientifically formulated and manufactured Nano AD3E liquid supplement for poultry animals contains nano sized vitamins encapsulated droplets (<200 nm) for direct absorption into the bloodstream. This nano form increases surface area, solubility and dissolution rate as well as prevents the degradation in the gastrointestinal tract, such as variations in pH levels, enzymatic breakdown, and inter-animal differences.

NANO FORMED VITAMIN A, D3 AND E PROVIDE an astonishing increase in  absorption (min x4) within the body, resulting in significantly enhanced bioavailability.

The aim is to achieve maximum bioavailability and optimal utilization for promoting peak poultry health.

Based on a study to investigate of bioavailability and effects of Nano Vitamin D3 supplement in broiler chickens, Nano Vitamin D3 supplementation showed higher bioavailability, growth performance, bone mineralization and bone characteristics than micro-Vitamin D3 supplement.

Studies have demonstrated that the nano supplementation increases the surface area and surface activity, which enhances absorption and thereby the utilization of vitamins (Ahn, 2010; Cai et al., 2012). Additionally, nano multivitamin supplementation showed higher bioavailability compared to micro vitamin supplements in broiler chickens, providing increased growth performance, immunity, and improvement in feed conversion ratio).

 Sheikhsamani et al. (2016) demonstrated that nano- multivitamin in a significant increase in the average weight and daily weight gain of broiler chicks during the starter period compared to conventional multivitamin supplementation. Zhang et al. (2010) studied the effect of composite vitamin nano-emulsion on growth performance and immunity of broilers and concluded that composite vitamin nano-emulsion could be used to increase the growth performance and immunity in the broiler.

KEY FACTS

ZOEUTICALS’ PHARMACEUTICAL NANOTECHNOLOGY PRODUCTIONS HAVE DEVELOPED A SOLUTION NOT ONLY INCREASE THE ABSORPTION OF NUTRIENTS SUCH AS VITAMIN AD3E WHICH HAVE LOW BIOAVAILABILITY IN CONVENTIONAL DOSAGE FORMS BUT ALSO TO MINIMIZE DEPENDENCE ON DRUGS, MAINLY ANTIBIOTICS.

Vitamins A, D3, and E contribute to improved egg quality, including shell strength and yolk color, as well as reproductive performance and immune system support. Vitamin E, in particular, is associated with fertility and hatchability in layers and breeders and is known as a powerful antioxidant. Vitamin D plays a role in calcium metabolism and bone development while influencing eggshell quality. Moreover, they are essential for proper growth and weight gain in broilers and chicks. Vitamin A is crucial for vision and overall growth.

VITAMIN E

Vitamin E, specifically alpha-tocopherol, serves as a natural antioxidant, enhancing the growth performance and physiological and immunological well-being of broiler chickens. Its capacity to reduce lipid peroxidation and neutralize free radicals in both skeletal muscle and plasma contributes to these benefits. Clinical signs of vitamin E deficiency include conditions such as exudative diathesis, muscular myopathy, and encephalomalacia in chicks, along with subclinical manifestations like slow growth, reduced fertility, and increased susceptibility to health issues. Additionally, Vitamin E plays a crucial role in enhancing immune functions, both humoral and cell-mediated, as highlighted by Rizvi et al. (2014).

Furthermore, Vitamin E protects sub-cellular and cellular membranes’ phospholipids from lipid oxidation, ensuring the maintenance of tissue and cell functionality and morphological integrity. Studies have shown that Vitamin E improves the antioxidant defense, immune response, and physiological functions of birds.

In commercial broilers, dietary supplementation with Vitamin E has been found to significantly enhance immune response and increase antioxidant concentrations in the liver. Vitamin E also aids in disease resistance and prevention by modulating the immune system through macrophage activation and antibody production, as noted by Weber (2009).

VITAMIN D3

Vitamin D3 serves as a crucial nutrient for promoting bone growth and plays a vital role in various biological pathways, including immune function, calcium (Ca) homeostasis, and cellular proliferation and differentiation. It is intricately linked to several physiological processes such as bone mobilization, mineralization, and the absorption of phosphorus (P) and calcium. The supplementation of vitamin D facilitates intestinal absorption of phosphorus and calcium, prompting the production of calcium-binding proteins in the mucosa. This activation of the calcium-activated tenderization complex is driven by an increase in plasma calcium concentration.

In broiler chicks, dietary supplementation of Vitamin D3 has been shown to reduce the incidence of tibial dyschondroplasia and positively impact bone quality (Browning et al., 2012). For laying hens, vitamin D contributes to optimal skeletal system function, strengthening claws, beaks, and bones. Additionally, it positively influences the quality of eggshells produced by layers. Studies by Shojadoost et al. (2015) indicate that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) possesses immunomodulatory properties in chicken macrophages. Rodriguez-Lecompte et al. (2016) found that vitamin D induces the upregulation of both pro- and anti-inflammatory cytokines.

Vitamin D3 can enhance the utilization of calcium and phosphorus by laying birds (Adhikari et al., 2020). Ultimately, the repercussions of vitamin D deficiency are severe and include conditions such as rickets, poor growth, compromised immune response, and reduced production. Therefore, vitamin D plays a crucial role in supporting bone growth and development, immunity, and stabilizing calcium-phosphorus metabolism in poultry.

VITAMIN A

Vitamin A is essential for various aspects of poultry health, including visual development, growth, reproductive physiology, and the maintenance of epithelial and skeletal integrity (Weber, 2009). It also plays a crucial role in supporting an optimal immune response, reducing susceptibility to infections. When faced with heat stress, supplementing vitamin A at levels higher than those recommended is preferable, as it aids in the normal development of reproductive organs and membrane integrity in laying hens (Kaya and Yildirim, 2011).

Adding vitamin A to the diet can prevent the inhibition of growth performance in poultry that may be deficient in this vitamin (Yuan et al., 2014). The levels of vitamin A needed to maximize immunocompetence have been shown to be much higher than those necessary for feed efficiency and optimum growth (Friedman and Sklan, 1997). Vitamin A is essential for maintaining the integrity of epithelial tissues, acting as the primary defense against the entry of pathogens. It also plays a role in increasing antibody synthesis against pathogens that may enter the body (Das et al., 2011).

Furthermore, under heat stress, vitamin A serves as a vital antioxidant, reducing lipid peroxidation (Abd El-Hack et al., 2015). Its supplementation has been shown to improve the development and growth of the reproductive system, accompanied by high levels of follicle-stimulating hormone (Fu et al., 2000). In summary, vitamin A enhances the overall productive performance, immunity, and reproductive system of poultry.

References

1.Sheikhsamani, et al, ‘The Bioavailability and Effects of Nano-Vitamin D3 and Micro-Vitamin D3 on Performance and Bone Characteristics in Broiler Chickens’, Poultry Science Journal, 2022, 10(2): 203-213
2.Alagawany et al., ‘Nutritional significance of amino acids, vitamins and minerals as nutraceuticals in poultry production and health – a comprehensive review’, 2020, VETERINARY QUARTERLY 2021, VOL. 41, NO. 1, 1–29 https://doi.org/10.1080/01652176.2020.1857887
3.Raza M., “Nanoemulsions” Lipid-Based Nanocarriers for Drug Delivery and Diagnosis, 2017
4.Mozafari et al., ‘ Recent trends in the lipid-based nanoencapsulation of antioxidants and their role in foods, Sci Food Agric 86:2038–2045, 2006
5.Fathi et. al, ‘Nanoencapsulation of food ingredients using lipid based delivery systems http://dx.doi.org/10.1016/j.tifs.2011.08.003, 2012
6.Alida Melse Boonstra, ‘ Bioavailability of Micronutrients From Nutrient-Dense Whole Foods: Zooming in on Dairy, Vegetables, and Fruits https://www.frontiersin.org/articles/10.3389/fnut.2020.00101/full, 2020
Farugui et al, ‘Perfusion Study On Rat Small Intestine Exposed To Cholera Toxin To ObserveAbsorptionOfWaterAndElectrolytesFromALiposomeBasedORS,http://www.alliedacademies.org/parasitic-diseases-diagnosis-therapy/ ISSN: 2591 7846